Diseases of a prostate affect many men 40 years are more senior. Very hard and quite often everything comes to end fighting with them surgical intervention. The drug “Propecia” is capable to improve significantly a condition of the man, despite high risk of development of side effects.
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Principle of action
Active ingredient in drug – Finasterid. This synthetic compound, is a specific competitive inhibitor 5 – II — alpha reductases of a desmoenzyme which turns testosterone into more active androgen — dihydrotestosterone. At a benign hyperplasia of a prostate its increase depends on transformation of testosterone into dihydrotestosterone in a prostate. Finasterid highly effectively reduces concentration of dihydrotestosterone both in a blood plasma, and in prostate gland tissue. Suppression of formation of dihydrotestosterone is followed by reduction of the sizes of a prostate, increase in the maximum speed of urination and decrease in expressiveness of the symptoms connected with a prostate hyperplasia.
Finasterid has no affinity to receptors of androgens.
According to results of clinical trial in which patients with moderately or considerable the expressed symptoms of a benign hyperplasia of a prostate and its increase participated, Finasterid reduced the frequency of emergence of an acute ischuria from 7/100 to 3/100 for the 4-year period, and frequency of need for surgical intervention (a transurethral resection of a prostate or a prostatectomy) — from 10/100 to 5/100. These changes were also associated with improvement of symptomatology of a benign hyperplasia of a prostate, steady reduction of volume of a prostate approximately for 20% and stable increase in speed of current of urine.
Before looking for Propecia study indications to its use:
• Treatment of a benign hyperplasia of a prostate;
• Prevention of complications at a benign hyperplasia of a prostate;
• Reduction of the sizes of the increased prostate and elimination of the accompanying symptoms;
• Delay of progressing of a benign hyperplasia of a prostate.
Drug possesses a number of contraindications:
• Individual intolerance;
• Age to 18 years.
Propecia by FDA belong to class X – the drugs prohibited to use for pregnant women.
The most frequent side effects of use of drug:
• Decrease in a libido;
• Disturbance of an erection, ejaculation;
• Skin rash.
At reception of Propecia hair loss it is observed extremely seldom.
Forms of release and dosage
Both the brand, and its generics are issued in the tableted form. You can find tablets on 5 or on 10 mg.
Use of a finasterid (Propecia) at treatment of a benign hyperplasia of a prostate allows to influence effectively symptoms of the lower uric ways both when using as monotherapy, and in combination with a-adrenoblockers. At the same time the data obtained in recent years do expedient purpose of a finasterid as prophylactic of development of a prostate cancer.