Cialis – one of the most modern and effective drugs for fight against erectile dysfunction. Drug belongs to the same group of compounds, as the known Viagra, but has higher performance and smaller amount of side effects.

buy cialis

Medication: Cialis (Tadalafil)
Dosage: 60 mg, 40 mg, 20 mg, 10 mg
Price: from $1.12 per pill
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Main active ingredient

Drug is produced in tablets on 5, 10 and 20 mg. Active ingredient is Cialis’s part tadalafit. It belongs to the class of inhibitors of phosphodiesterase-5 (FDE-5).

Principle of action

During sexual excitement nitrogen oxide begins to be produced by an endothelium of vessels of a penis. It leads to increase in concentration of guanylate cyclase, tsGMF. The last, in turn, promotes relaxation of smooth muscle cells. Inflow of blood is provided thanks to relaxation of smooth muscles of cavernous bodies of a penis and the vessels located in them. As a result – the erection develops.

For control of degree and duration of an erection in parallel with tsGMF enzyme – fosfodiestaraza-5 is produced. It destroys surplus of tsGMF. Cialis blocks FDE-5 that leads to accumulation of tsGMF and stronger, long erection.

In addition to FDE-5, there are other FDE types located in a retina, a myocardium, skeletal muscles, a wall of vessels. The main side effects of Viagra (face reddening, abnormal color perception, falling of arterial blood pressure) are connected from it rather small selectivity concerning action on FDE-5 and influence on other types of phosphodiesterase.

Cialis is deprived of similar shortcomings. He connects with FDE-5 700 times stronger, than with FDE-6. With others like phosphodiesterase this value exceeds 1000, and sometimes and 10000 times.

Indications

Drug is used at:

Treatment of frustration of an erection;
To symptomatology from lower parts of urinary tract at a benign hyperplasia of a prostate;
Erectile dysfunction against the background of it is good-quality a prostate hyperplasia.

Contraindications

Cialis is contraindicated to men at:
Intolerance of the drug or its active ingredient;
Allergies to a tadalafil;
Reception of any kinds of nitrates (Nitroglycerine, Isosorbide, Kardiket and so forth);
Intake of alpha adrenoblockers (Prazozinum, Doxazosinum);
Heavy renal failure.

Side effects

At Cialis’s reception treat the most frequent complications:
Head pains;
The feeling of rush of blood suits;
Difficulty of nasal breath;
Digestion disturbance;
Dorsodynia, muscles.

Application instruction

Pill is taken inside, not chewed and is not crushed in any way, without binding to meal, washed down with moderate amount of liquid.

In case of erectile dysfunction Cialis’s dosage is selected individually. If the intimate proximity occurs more often than 2 times a week, then tablets are drunk every day. The first reception has to make 5 mg. If the positive effect was absent or was insufficient, then increase in a dosage on 2.5-5 mg to desirable result is possible.